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…导师教师师资介绍简介-张胜祥 – 兰州大学师资导 – Free考研…(导师 讲师)

张胜祥 教授、博导兰州大学生命科学学院教授,博士生导师 自个简历 科研&作用 教育情况 论文&专著 更多信息

联络方法职  称: 教授地址部分: 动物学与生物医学系 单位: 天演楼447联络电话: 传真号码: 电子邮件: sxzhang自个主页: 学习阅历2007-2009 美国纽约大学, skirball生物分子医学研讨所,博士后2007-2009 postdoctoral training, new york university2001-2007 加拿大不列颠哥伦比亚大学,脑研讨中心,博士2001-2007 ph. d., the university of british columbia1995-1998 兰州大学,生物系,硕士1995-1998 m.s., department of biology, lanzhou university1991-1995 兰州大学,生物系,学士1991-1995 b.s., department of biology, lanzhou university作业阅历2009-如今 兰州大学,生命科学学院,动物学与生物医学系,萃英****2009-present school of life sciences, lanzhou university2007-2009 美国纽约大学, skirball生物分子医学研讨所,博士后2007-2009 skirball institute of biomolecular medicine, new york university1998-2000 南京大学,生物系,助教1998-2000 department of biology, nanjing university社会作业我国神经科学学会理事,我国微循环学会神经维护与恢复专业委员会委员,甘肃省动物学会副理事长,甘肃省细胞生物学学会理事,甘肃实验动物资业技能立异战略联盟常务理事研讨方向1、脑中风后突触规划可塑性的细胞和分子机理。突触是神经元之间的联接点,是学习和回想的规划基础。课题组首要研讨方向之一是谈论脑中风后影响突触规划可塑性的细胞和分子机理。课题组使用转基因荧光小鼠,活体内双光子荧鲜明微成像和内源性光学信号成像等技能,以及细胞生物学、分子生物学和行为学等研讨办法,测验提示病理条件下神经环路的改动与大脑功用恢复之间的联络。2、小胶质细胞激活和增殖的调控机制。小胶质细胞是中枢神经体系内具有免疫功用的细胞。在正常脑组织中,小胶质细胞处于静息态,对周围的组织起着监测和维护作用。在病理情况下,小胶质细胞被灵敏激活,并在损害区周围增生。课题组当前的快乐喜爱首要是使用多种转基因东西鼠,联系活体成像和细胞培育等办法谈论脑中风后小胶质细胞增生的功用及调控机制。3、生物荧光符号技能开发与使用。适于活细胞及活体符号的荧光探针的开发,血管符号及成像技能的开发与使用。4、陇药活性成分作用机制研讨。陇药活性成分作用机制研讨及其在严峻疑问疾病中的使用。项目作用掌管基金项目: 掌管国家天然科学基金面上项目4项, 甘肃省科技方案项目-科技支撑方案1项,高级学校博士学科点专项科研基金-博导类项目1项,神经科学国家要点实验室翻开课题2项;荣誉、获奖教育及辅导研讨生情况辅导研讨生: 硕士研讨生招生方向:发育神经生物学; 注:硕士研讨生招生专业为发育生物学(071008) 博士研讨生招生方向:发育神经生物学、动物生理学。 教育: 主讲本科生课程:发育生物学; 主讲研讨

生课程:发育生物学研讨办法,动物生理学专题等。宣告论文及专著publications: for most recent publications, please visit my orcid profile:https://orcid.org/0000-0001-6524-9673xie, w., gong, x.t., cheng, x., cao, j., zhao, j., zhang, h.l. & zhang, s. (2021) limpid: a versatile method for visualization of brain vascular networks. biomaterials science.yang, y.p., qi, f.j., qian, y.p., bao, x.z., zhang, h.c., ma, b., dai, f., zhang, s.x. & zhou, b. (2021) developing push-pull hydroxylphenylpolyenylpyridinium chromophores as ratiometric two-photon fluorescent probes for cellular and intravital imaging of mitochondrial nqo1. analytical chemistry 93:2385-2393.li, t., zhao, j., xie, w., yuan, w., guo, j., pang, s., gan, w.b., gomez-nicola, d. & zhang, s. (2021) specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage. journal of neuroinflammation 18:81.hu, g., zhong, m., zhao, j., gao, h., gan, l., zhang, h., zhang, s. & fang, j. (2021) fluorescent probes for imaging protein disulfides in live organisms. acs sensors 6:1384-1391.roth, s., cao, j., singh, v., tiedt, s., hundeshagen, g., li, t., boehme, j.d., chauhan, d., zhu, j., ricci, a., gorka, o., asare, y., yang, j., lopez, m.s., rehberg, m., bruder, d., zhang, s., gross, o., dichgans, m., hornung, v. & liesz, a. (2021) post-injury immunosuppression and secondary infections are caused by an aim2 inflammasome-driven signaling cascade. immunity.wang, l., zhu, l., liu, j. & zhang, s. (2021) long-term high-resolution in vivo imaging of cerebral cortical structures following ischemic stroke. biophysics reports 6:127-136.liu, x., shang, s., chu, w., ma, l., jiang, c., ding, y., wang, j., zhang, s. & shao, b. (2021) astragaloside iv ameliorates radiation-induced senescence via antioxidative mechanism. journal of pharmacy and pharmacology 72:1110-1118.zhao, j., qu, y., gao, h., zhong, m., li, x., zhang, f., chen, y., gan, l., hu, g., zhang, h., zhang, s. & fang, j. (2021) loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe. chemical communications (cambridge, england) 56:14075-14078.long, y., liu, j., tian, d., dai, f., zhang, s. & zhou, b. (2021) cooperation of esipt and ict processes in the designed 2-(2′-hydroxyphenyl)benzothiazole derivative: a near-infrared two-photon fluorescent probe with a large stokes shift for the detection of cysteine and its application in biological environments. analytical chemistry 92:14236-14243.gong, x.t., xie, w., cao, j.j., zhang, s., pu, k. & zhang, h.l. (2021) nir-emitting semiconducting polymer nanoparticles for in vivo two-photon vascular imaging. biomaterials science 8:2666-2672.zhang, s. (2021) microglial activation after ischaemic stroke. stroke and vascular neurology 4:71-74.ju, f., ran, y., zhu, l., cheng, x., gao, h., xi, x., yang, z. & zhang, s. (2021) increased bbb permeability enhances activation of microglia and exacerbates loss of dendritic spines after transient global cerebral ischemia. frontiers in cellular neuroscience 12:236.zhu, l., wang, l., ju, f., khan, a., cheng, x. & zhang, s. (2021) reversible recovery of neuronal structures depends on the degree of neuronal damage after global cerebral ischemia in mice. experimental neurology 289:1-8.zhu, l., wang, l., ju, f., ran, y., wang, c. & zhang, s. (2021) transient global cerebral ischemia induces rapid and sustained reorganization of synaptic structures. journal of cerebral blood flow and metabolism 37:2756-2767.khan, a., ju, f., xie, w., tariq hafeez, m., cheng, x., yang, z., zhu, l., li, t. & zhang, s. (2021) transcriptomic analysis reveals differential activation of microglial genes after ischemic stroke in mice. neuroscience 348:212-227.wang, c., tao, s., fang, y., guo, j., zhu, l. & zhang, s. (2016) infiltrating cells from host brain restore the microglial population in grafted cortical tissue. scientific reports 6:33080.li, l., du, y., ju, f., ma, s. & zhang, s. (2016) calcium plays a key role in paraoxon-induced apoptosis in el4 cells by regulating both endoplasmic reticulum- and mitochondria-associated pathways. toxicology mechanisms and methods 26:211-20.li, t. & zhang, s. (2016) microgliosis in the injured brain: infiltrating cells and reactive microglia both play a role. neuroscientist 22:165-70.li, d., guo, j., zhou, x., chang, c. & zhang, s. (2016) the complete mitochondrial genome of phrynocephalus helioscopus (reptilia, squamata, agamidae). mitochondrial dna a dna mapp seq anal 27:1846-7.sun, c.-l., liao, q., li, t., li, j., jiang, j.-q., xu, z.-z., wang, x.-d., shen, r., bai, d.-c., wang, q., zhang, s.-x., fu, h.-b. & zhang, h.-l. (2015) rational design of small indolic squaraine dyes with large two-photon absorption cross section. chemical science 6:761-769.tang, p., zhang, y., chen, c., ji, x., ju, f., liu, x., gan, w.b., he, z., zhang, s., li, w. & zhang, l. (2015) in vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury. scientific reports 5:9691.wang, y., wang, q., lv, s. & zhang, s. (2015) different protein of echinococcus granulosus stimulates dendritic induced immune response. parasitology 142:879-89.zhang, y., zhang, l., ji, x., pang, m., ju, f., zhang, j., li, w., zhang, s., he, z., gan, w.b. & tang, p. (2015) two-photon microscopy as a tool to investigate the therapeutic time window of methylprednisolone in a mouse spinal cord injury model. restorative neurology and neuroscience 33:291-300.liu, c.j., du, b., liu, n.f., bao, s.j. & zhang, s. (2014) sex-specific parental care strategies via nestling age: females pay more attention to nestling demands than males do in the horned lark, eremophila alpestris. zoological science 31:348-52.li, t., pang, s., yu, y., wu, x., guo, j. & zhang, s. (2013) proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. brain 136:3578-88.wang, j., feng, x., du, y., wang, l. & zhang, s. (2013) combination treatment with progesterone and rehabilitation training further promotes behavioral recovery after acute ischemic stroke in mice. restorative neurology and neuroscience 31:487-99.lu, b., li, t., zhao, h., li, x., gao, c., zhang, s. & xie, e. (2012) graphene-based composite materials beneficial to wound healing. nanoscale 4:2978-82.zhang, s., wang, j. & wang, l. (2010) structural plasticity of dendritic spines. frontiers in biology 5:48-58.bhatt, d.h., zhang, s. & gan, w.b. (2009) dendritic spine dynamics. annual review of physiology 71:261-82.zhang, s. & murphy, t.h. (2007) imaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo. plos biology 5:e119.enright, l.e., zhang, s. & murphy, t.h. (2007) fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer v neuron dendritic tufts within single neurons in vivo. journal of cerebral blood flow and metabolism 27:1185-200.zhang, s., boyd, j., delaney, k. & murphy, t.h. (2005) rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia. journal of neuroscience 25:5333-8.zhang, s. & murphy, t.h. (2004) ca(2+)-independent spine dynamics in cultured hippocampal neurons. molecular and cellular neurosciences 25:334-44.其它信息

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